General Information

  • ID:  hor006697
  • Uniprot ID:  Q9PU41
  • Protein name:  Cholecystokinin-70
  • Gene name:  CCK
  • Organism:  Gallus gallus (Chicken)
  • Family:  Gastrin/cholecystokinin family
  • Source:  Animal
  • Expression:  By dietary protein, amino acids and medium-chain triacylglycerol. |In the small intestine, the major production site is around the vitelline diverticulum.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0001764 neuron migration; GO:0007165 signal transduction; GO:0007409 axonogenesis; GO:0007586 digestion
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon

Sequence Information

  • Sequence:  APSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDF
  • Length:  70(49-118)
  • Propeptide:  MYGGICICVLLAALSVSSLGQQPAGSHDGSPVAAELQQSLTEPHRHSRAPSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS
  • Signal peptide:  MYGGICICVLLAALSVSSLG
  • Modification:  T64 Sulfotyrosine;T70 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  CCKAR
  • Target Unid:  A0ZPS0
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PU41-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006697_AF2.pdbhor006697_ESM.pdb

Physical Information

Mass: 895067 Formula: C339H537N103O100S2
Absent amino acids: C Common amino acids: AGRLS
pI: 10.69 Basic residues: 11
Polar residues: 20 Hydrophobic residues: 22
Hydrophobicity: -57.29 Boman Index: -15241
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 68.43
Instability Index: 4110.14 Extinction Coefficient cystines: 8480
Absorbance 280nm: 122.9

Literature

  • PubMed ID:  11072120
  • Title:  Identification of ostrich and chicken cholecystokinin cDNA and intestinal peptides.
  • PubMed ID:  3620999
  • Title:  Cholecystokinin octapeptides purified from chinchilla and chicken brains.
  • PubMed ID:  8355559
  • Title:  Effects of cholecystokinin and gastrin on gastroduodenal motility and coordination in chickens.
  • PubMed ID:  8637413
  • Title:  
  • PubMed ID:  9039026
  • Title:  
  • PubMed ID:  10069039
  • Title: